A Note on Yellow Discoloration in Atebrin Therapy *Rearranged by Editor.

n !. "fy ?/ atebrin ingestion, but it is usually iceable in the conjunctiva, skin and urine within a week or ten days of beginning the treatment. This delayed manifestation may be the outcome of cumulation in the various tissues coating of the body and the efforts at excretion through the urine when the concentration has reached a certain point. Atebrin is a drug possessing cumulative action and a slow excretion rate, and these factors render a helpinghand in prolonging retention and the associated pigmentation. When the excretion commences the urine presents a santonin-like colour, which is however less marked when the urine is less acid or when the patient is taking citrates or alkalies. Chemically its presence can be easily demonstrated by extracting it with ether from urine rendered alkaline and then dissolving it in concentrated sulphuric acid when ' a definite fluorescent yellow colour appears The pigmentation Of the skin has been seen to persist longer than the discoloration of the urine, for in the later stages, when the urine ceases to be positive to the eye or the chemical test, the skin keeps on the pigment though to